The 2013 7th Workshop on Recent Issues in Bioanalysis was held in Long Beach, California, USA, where close to 500 professionals from pharmaceutical and biopharmaceutical companies, CROs and regulatory agencies convened to discuss current topics of interest in bioanalysis. These 'hot' topics, which covered both small and large molecules, were the starting point for fruitful exchanges of knowledge, and sharing of ideas among speakers, panelists and attendees. The discussions led to specific recommendations pertinent to bioanalytical science. Such as the previous editions, this 2013 White Paper addresses important bioanalytical issues and provides practical answers to the topics presented, discussed and agreed upon by the global bioanalytical community attending the 7th Workshop on Recent Issues in Bioanalysis.

Several new protic ionic liquids (PILs) were prepared by mixing trifluoroacetic acid (TFA) with various heterocyclic amines using different base:acid ratios (1:1 and 1:2). Their specific conductivities have been measured by electrochemical impedance spectroscopy and were found ranging from 0.71 to 9.07 mS • cm -1 at 27.0 °C. In all cases, the conductivity of a given ionic liquid increased with a higher proportion of acid (1:2 ratio) which is explained mainly a smaller viscosity obtained in these conditions. Indeed, in most PILs, the dynamic viscosity (10.3-484 cp at 27.0 °C) is decreased by a higher acid proportion. Both parameters were used to construct a Walden plot in order to evaluate the quality of these protic ionic liquids (PILs) and compare them with common room temperature (RT) molten salts. The physicochemical properties of the PILs were then compared with the specific capacitance values obtained with a thermally prepared RuO 2 electrode in these ionic liquid electrolytes. This work brings evidence that pseudocapacitance is involved in the energy storage mechanism of the PILs studied here and shows that PILs could eventually be used as electrolytes in metal oxide-based supercapacitors.

No abstract

No abstract

The IAE procedure coupled with VAMS is immune to HCT biases affecting sampling volume and recovery.