Ten years after treatment, accelerated, hypofractionated whole-breast irradiation was not inferior to standard radiation treatment in women who had undergone breast-conserving surgery for invasive breast cancer with clear surgical margins and negative axillary nodes. (ClinicalTrials.gov number, NCT00156052.)

The more convenient 22-day fractionation schedule appears to be an acceptable alternative to the 35-day schedule.

No abstract

Smoking status should be documented in all future trials of RT in SHNC to allow for pooled analyses with sufficient power to address this question.