Myristica fragrans, also known as nutmeg is a spice that cures various diseases. This study aimed to synthesize silver nanoparticles from a hydroethanolic extract of Myristica fragrans seeds (MFHE) and evaluate their anti-diabetic properties. To MFHE, AgNO 3 solution was added and exposed to sunlight to produce silver nanoparticles from hydroethanolic seed extract of Myristica fragrans (MFHENP). The MFHENP was characterized by numerous techniques. UV-visible spectroscopy con rmed the formation of silver nanoparticles by the absorption peak at 430nm. Scanning electron microscopy (SEM) studies revealed the shape and size of the particles at the range of 50-60nm. Energy-dispersive X-ray spectroscopy (EDX) disclosed the presence of silver ions. X-ray diffraction spectrum con rmed the crystalline nature of silver nanoparticles by the peak at 39 o . FTIR analysis revealed the functional groups present in MFHE as well as in MFHENP and Zeta potential analysis was found to be 14mV. Furthermore, in-vitro anti-diabetic activity was investigated. MFHENP showed signi cant e ciency against the inhibition of alpha-amylase and alpha-glucosidase enzymes and also MFHENP retarded the glucose transport across the membrane which is analyzed by glucose diffusion and glucose uptake assays.Acarbose is used as a standard for all these methods and MFHENP e ciency proves their therapeutic potential for the treatment of diabetes mellitus.

Nanoparticles are gaining interest in biomedical applications due to its importance such as anti-bacterial, anti-fungal and anti-cancer agents. Conventional methods for the synthesis of metal nanoparticles involves toxic reagents which produce harmful by-products and are hazardous to the environment. To overcome these limitations, green synthesis of nanoparticles was established. Eco-friendly methods using plant extracts are gaining popularity due to the abundance of raw materials and the production of non-toxic by-products threatening to the environment. Moreover, the nanoparticles synthesized from the plant extract are cost-effective. In addition, nanoparticles produced by green synthesis methods produces synergetic effect where both the nanoparticles as well as the natural bioactive constituents of the plant influence the biocidal properties. Different methods namely heating in water bath, microwave oven and exposure to bright sunlight were adopted for the synthesis of silver nanoparticles. Plant extract based synthesis of silver nanoparticles was eco-friendly and shows an alternative promise in bio-medical applications and it undertakes the negative effects of synthetic drugs.

Myristica fragrans, also known as nutmeg is a spice that cures various diseases. This study aimed to synthesize silver nanoparticles from a hydroethanolic extract of Myristica fragrans seeds (MFHE) and evaluate their anti-diabetic properties. To MFHE, AgNO3 solution was added and exposed to sunlight to produce silver nanoparticles from hydroethanolic seed extract of Myristica fragrans (MFHENP). The MFHENP was characterized by numerous techniques. UV-visible spectroscopy confirmed the formation of silver nanoparticles by the absorption peak at 430nm. Scanning electron microscopy (SEM) studies revealed the shape and size of the particles at the range of 50-60nm. Energy-dispersive X-ray spectroscopy (EDX) disclosed the presence of silver ions. X-ray diffraction spectrum confirmed the crystalline nature of silver nanoparticles by the peak at 39o. FTIR analysis revealed the functional groups present in MFHE as well as in MFHENP and Zeta potential analysis was found to be 14mV. Furthermore, in-vitro anti-diabetic activity was investigated. MFHENP showed significant efficiency against the inhibition of alpha-amylase and alpha-glucosidase enzymes and also MFHENP retarded the glucose transport across the membrane which is analyzed by glucose diffusion and glucose uptake assays. Acarbose is used as a standard for all these methods and MFHENP efficiency proves their therapeutic potential for the treatment of diabetes mellitus.

Diabetes mellitus is a common metabolic disorder in which the human body does not produce insulin hormone, this leads to the increase in blood glucose levels. Diabetes infects more than 387 million individuals globally, posing a significant threat to both personal well-being and global economies. Normally, medicinal plants are highly used for the treatment of diabetes mellitus but some spices also have the efficiency to treat diabetes. Still, spices which we are using as ingredients plays important role in foods also have the ability to treat diabetes. This article describes the anti-diabetic activity of those medicinal spices.