Dye-sensitised solar cells (DSSCs) are an important part of research on renewable energy sources as they are less complicated to manufacture and cost less than several other types of solar cells. The performance of DSSC with a combination of mesoporous zinc oxide and natural dyes are simulated using COMSOL Multiphysics. Numerical expression of the electrical properties of a dye-sensitised solar cell is applied to a two-dimensional structure to form an electrical model. Optical properties of the natural dyes are then coupled with this electrical model. The variables tested are thickness of the photoanode layer and absorption coefficient of dyes. Efficiency of the simulated zinc oxide solar cell with N719 dye is 12.4%. Maximum power of 0.309 µW is obtained at a photoanode thickness of 600 nm with current density of 16.815 mA/cm 2 and voltage of 0.756 V. The natural dyes simulated are chlorophyll, betalain and anthocyanin. Of the three, the one with the highest absorption coefficient i.e., betalain resulted in the highest efficiency solar cell. The results were more favourable than several simulations studying titanium dioxide based DSSC.