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A double blind study was performed on 53 patients in introducing anti-inflammatory drugs by iontophoresis. The objective was to see if local iontophoretic administration of an antiinflammatory drug to patients with tendonitis at the shoulder joint would achieve results similar to those obtained by local injection of the drug. Patients below the age of 45 years with shoulder dysfunction related to primary tendonitis responded to iontophoresis steroid administration. Patients in the age group above 45 years with a primary diagnosis of cervical degenerative change demonstrated less pain relief in shoulder tendonitis whether the steroids were administered by local injection or by iontophoresis. J Orthop Sports Phys Ther 1982;4(2):103-108.