In our research, the essential objective was to find out the relationship of fear of failure, perceived ease of use, intrinsic motivation, and women entrepreneur attitude and women entrepreneur behavior. This research tested the direct relationship of Fear of Failure, Perceived Ease of Use, Intrinsic Motivation and outcome Women Entrepreneur Behavior also tested the Women Entrepreneur Attitude as mediator in the relationship between the antecedents and burnout. There was a sample of 348 (RV Krejcie, 1970) employees of women entrepreneur in Nigeria includes entrepreneurs. In order to analyze the data for this research, we used structural equation model to analyze the data and check the hypothesis. Our finding shows that women entrepreneur attitude mediates the relationship of Fear of Failure, Perceived Ease of Use, Intrinsic Motivation’s and Women Entrepreneur Behavior. Our empirical finding recommends that implications for all the African countries especially for Nigeria.