Background: Hydrogen Sulphide (H2 S) and Nitric Oxide (NO) are gasotransmitters with neuroprotective and antioxidant properties which can be produced by the gastric microbiota.

Some cancers have been attributed to Fusobacterium nucleatum (which belongs to PO-associated pathogens), especially colonic cancer [14].The severity of PO is also associated (even attributed by some authors) to the expression of herpes viruses, including cytomegalovirus [15][16][17][18]. The association of cytomegalovirus and Aggregatibacter actinomycetemcomitans could explain severe progression of PO [19].Multiple herpesvirus infection is detected in patients with severe chronic PO. Herpes Simplex Virus (HSV)-1 (46.6%) are the most common herpesvirus followed by HSV-2 (34.6%), Epstein-Barr Viruses (EBV) (30.6%), and Cytomegalovirus (CMV) (19.3%) [20]. Cytomegalovirus has also been implicated in the occurrence of central

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Volume 5 -Issue 2 consideration since they are suspected to favour gastroparesis [21][22][23][24] or periodontitis [25][26][27][28][29][30]. Cytomegalovirus has also been implicated in the occurrence of depression [31,32], obesity [33,34], or UC [35]. Material and MethodsThis is a descriptive retrospective epidemiological study. Data were collected during the normal course of routine gastroenterological consultations for Small Intestinal Bowel Overgrowth (SIBO), from January 15, 2020 until March 15, 2020. There was no hypothesis testing before data collection, no data collection beyond that which is part of routine clinical practice, no scheduled data analysis before the work has already been done. This retrospective analysis of Case Series cannot therefore be qualified as "research" and does not requires approval from ethics boards designed to protect humans involved in clinical research, according to the International Committee of Medical Journal Editors (ICMJE). Inclusion criteriaPatients consulting for SIBO and who underwent a breath test. Patients should provide with a full medical history, especially