A personalized dosing protocol of colistin was effective, with low nephrotoxicity, among critically ill Vietnamese patients with low body weight. Further studies are warranted for assessing the efficacy and toxicity in a larger cohort.

This paper proposes a weak form for the contact problem with Coulomb friction, written as extension of the standard virtual work principle and involving both the displacements and the multipliers defined on the reference contact surface. The mixed relationship is shown to be equivalent to the strong form of the initial/boundary value contact problem, and it can be discretized by means of the finite element method in a simple way. Typical numerical examples are given to assess the efficiency of the formulation in statics and dynamics.

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