Cationic lipids have long been known to serve as antibacterial and antifungal agents. Prior efforts with attachment of cationic lipids to carbohydrate-based surfaces have suggested the possibility that carbohydrate-attached cationic lipids might serve as antibacterial and antifungal pharmaceutical agents. Toward the understanding of this possibility, we have synthesized several series of cationic lipids attached to a variety of glycosides with the intent of generating antimicrobial agents that would meet the requirement for serving as a pharmaceutical agent, specifically that the agent be effective at a very low concentration as well as being biodegradable within the organism being treated. The initial results of our approach to this goal are presented.
S y n t h e s i s a n d T h e r m o c h e m i c a l P r o p e r t i e s o f H y d r o x y A m m o n i u m S a l t sAbstract: A series of stereoisomeric ammonium salts containing the 1,2-dihydroxypropyl unit were prepared. Of particular interest to us are those salts that were found to be ionic liquids, although some are solids at room temperature. The thermochemical properties of these new materials are reported.
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