Objectives: To compare the efficacy of antibiotic administration prior to skin incision and after clamping of umbilical cord as attempt for preventing the rates of maternal post-caesarean infectious morbidities and adverse neonatal outcomes. Methods:In this prospective randomized study design, 100 pregnant women prepared to undergo CS were randomized evenly into two groups based on time they received prophylactic antibiotics either half to one hour prior to skin incision (group-1) or immediately after cord clamping (group-2). The post-caesarean maternal infectious morbidities are the primary outcomes, whereas neonatal infectious morbidities are secondary outcomes.Results: Postpartum maternal infectious outcomes (fever, SSI, wound dehiscence, endometritis, UTI) were significantly lower in pre-incision group as compared to post-cord clamping group as well as the mean of maternal hospital stay respectively (P< 0.05). In spite the secondary neonatal outcomes found to be comparable among study's groups, but such differences did not reach the statistical significant. Conclusion:Apart from neonatal outcomes, preoperative administrations of antibiotic significantly reduce the maternal post-caesarean infectious morbidities in comparison to its intraoperative administration.