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The impact of channel fill level on internal forces during continuous twin screw wet granulation.

Micronisation, or fine grinding, is a key unit operation for many industries, with the spiral jet mill being popular as it is robust and reliable. Within this paper an analytical derivation for spiral jet mill cut size as a function of micronisation settings, gas thermodynamic properties and empirically derived constants for the material and mill is presented for the first time. This has been corroborated by experimental evidence and previously reported data in the academic literature and provides an insight into the interaction between aerodynamic particle classification and fine grinding. A scale up methodology is proposed for a high value material by using a small scale mill to determine the material specific constants of the high value material and a cheaper surrogate material to determine mill specific constants at increased scale.

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