No increased risk of malignancy was detected in this series, supporting the safety of radiosurgery. Pragmatically, in advising patients, the risks of malignancy would seem small, particularly if such risks are considered in the context of the other risks faced by patients with intracranial pathologies requiring radiosurgical treatments.

This phantom study assesses the accuracy of stereotactic localization using the Leksell G frame (Elekta Instruments AB, Stockholm, Sweden) with T1-weighted magnetic resonance imaging (Siemens 1.5 T Magnetom; Erlangen, Germany). The coordinates of an array of solid perspex rods were determined and compared with measured values in a series of transverse, coronal, and sagittal images. The maximum absolute errors observed (X = 2.7 mm, Y = 7.0 mm, Z = 8.0 mm) were discouraging. However, the more reasonable mean errors (X = 0.4 mm, Y = 0.7 mm, Z = 1.3 mm) reflect considerable variation in accuracy throughout the volume assessed and limitation of maximum errors to specific areas. We present details of the spatial variation and discuss possible mechanisms for improving accuracy. The overall results are of direct relevance only to the scanner used. These results are, however, an indication of the need to approach with caution stereotactic localization using magnetic resonance imaging and to emphasize the requirement for quality assurance and for a comprehensive study of the scanner's characteristics.

This is a systematic review of a consecutive series of 309 meningiomas treated with gamma knife stereotactic radiosurgery between 1994 and 2000. There was an extreme selection bias towards lesions unfavourable for surgery, determined by the patients referred for treatment: 70% of tumours involved the skull base, 47% specifically the cavernous sinus: 15% of patients had multiple meningiomatosis or type 2 neurofibromatosis. Tumour histology was the main determinant of growth control (p < 0.001), the 5-year actuarial control rates being 87% for typical meningiomas, 49% for atypical tumours and 0% for malignant lesions. Complications from radiosurgery were rare, occurring in 3% of tumours, and were most frequently trigeminal and eye movement disturbances treating cavernous sinus meningiomas. Given the problems inherent in managing these tumours, radiosurgery is a valuable strategy and adjuvant treatment for these meningiomas.

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