According to the needs generated by the industry, there is an urgent need to investigate the flow vibration response law of the elastic tube bundle of heat exchangers subjected to the coupling effect of shell and tube domain at different inlet flow velocities. In this paper, based on the continuity equation, momentum equation, turbulence model, and dynamic grid technology, the vibration response of the elastic tube bundle under the mutual induction of shell and tube fluids is studied by using pressure-velocity solver and two-way fluid-structure coupling (FSC) method. The results show that the monitoring points on the same connection block have the same vibration frequency, while the vibration amplitude is different. Monitoring point A is the most deformed by the impact of fluid in the shell and tube domain. When the inlet velocity( v shell = v tube = 0.15 , 0.4, 0.5 m/s) of shell and tube is low, the amplitude of tube bundle vibration in the Y direction is greater than that in X and Z direction, and the tube bundle produces periodic vibration in the vertical direction. The vibration equilibrium position of the tube bundle along the shell flow direction gradually moves up with the increase of the inlet velocity. The amplitude in the Y -direction of the elastic bundle decreases with the increase of shell-side and tube-side velocity. The relationship between the vibration amplitude in the Y direction and the entrance velocity is a linear function.