Based on the hypoxia prodrug moiety of p-nitrobenzyl, a selective ratiometric fluorescent sensor (RHP) for the detection of microenvironment hypoxia was designed and synthesized. RHP can be selectively activated by bioreductive enzymes (NTR) and results in an evident blue to green fluorescent emission wavelength change in both solution phases and in cell lines, which might be the first fluorescent ratiometric probe for hypoxia in solid tumors.

Reported here is the highly efficient separation of industrially important cis-and trans-1,2-dichloroethene (cis-DCE and trans-DCE) isomers by activated crystalline 2,2',4,4'tetramethoxyl biphen[3]arene (MeBP3) materials,M eBP3a. MeBP3 can be synthesized in excellent yield (99 %), and ac yclic pentamer is also obtained when using 1,2-dichloroethane as the solvent. The structure of MeBP3 in the CH 3 CN@MeBP3 crystal displays at riangle-shape topology, forming 1D channels through window-to-windowp acking. Desolvated crystalline MeBP3 materials,M eBP3a,p referentially adsorb cis-DCE vapors over its trans isomer.MeBP3a is able to separate cis-DCE from a5 0:50 (v/v) cis/trans-isomer mixture,y ielding cis-DCE with ap urity of 96.4 %i nas ingle adsorption cycle.S ingle-crystal structures and powder X-ray diffraction patterns indicate that the uptake of cis-DCE triggers as olid-state structural transformation of MeBP3, suggesting the adaptivity of MeBP3a materials during the sorption process.M oreover,t he separation can be performed over multiple cycles without loss of separation selectivity and capacity.

A new probe based on the Gabriel mechanism was designed and first used for hydrazine detection with high selectivity against other amines in aqueous solution. Importantly, the probe could be used for gas-state discrimination of hydrazine with different concentrations. Additionally, probe could also be applied for the imaging of hydrazine in living cells.