A novel colorimetric immunoassay for highly sensitive detection of respiratory syncytial virus (RSV), one of the leading causes of severe lower respiratory tract infections in all age groups, has been proposed based on Hg(2+)-stimulated peroxidase-like activity of gold nanoparticles-graphene oxide (AuNPs-GO) hybrids. This metal ion-enhanced immunoassay shows high promise in the field of biomedical sciences.

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Carbon dots (CDs) with average diameter of 3.1 ± 0.5 nm were facilely synthesized with candle soot through hydrothermal reaction in sodium hydroxide aqueous solution. The as-prepared CDs were covered with a lot of hydroxyls, possessed properties of good water-solubility, anti-photobleaching, salt tolerance, and low cytotoxicity, and had a fluorescence quantum yield (QY) of about 5.5%. The fluorescence of the hydroxyls-coated CDs could be selectively quenched by metal ions such as Cr 3+ , Al 3+ and Fe 3+ , which is because these metals can easily combine with the hydroxyl groups on the surface of CDs and induce aggregation of hydroxyls-coated CDs. Experiments showed that the quenching of Cr 3+ had a Sterm-Volmer constant of 1.03 × 10 7 M -1 with a liner range of 1.0-25.0 μM and detection limit of 60 nM (3σ). carbon dots, fluorescence, quantum yield, cytotoxicity, metal ions

Core–shell structural carbon quantum dots (CQDs) are prepared through a highly efficient self-exothermic reaction at room temperature, which possess 24.6% absolute quantum yield and can be well applied for analysis applications.