Background: Puberty is an important period for teenagers with intellectual disability (ID). In this period sexuality education and increasing social skills of adolescent and education of mothers become absolutely vital. The current research aimed to present a comprehensive educational program for promoting sexual knowledge and social skills mild intellectually disabled teenagers in puberty.Methods: This study is a sequential exploratory (qualitative – quantitative) mixed methods design that consists of three consecutive phases. In this study, following a qualitative approach, the researchers will explain state of sexual knowledge and social skills mild intellectually disabled teenagers in puberty. In the second phase, researchers will design an appropriate and comprehensive educational program for promoting sexual knowledge and social skills of MID adolescents and the education of their mothers. The suggested program of expert panel is approved based on prioritization guidelines and will be finalized for the execution. In the third stage, the effectiveness of educational program will be investigated in a semi-experimental study.Conclusions: Findings revealed that the educational program is appropriate MID adolescents and their mothers and will increase their sexual knowledge and social skills in puberty. Educational programs are important for teenagers with MID and their mothers. Family plays an important role in puberty of these adolescents.