In this contribution, porous hollow silica nanoparticles using inorganic nanosized ZnS as a template were prepared. The hydrothermal method was used to synthesize pure ZnS nanospheres material. The ZnS@SiO2 core-shell nanocomposites were prepared using a simple sol-gel method successfully. The hollow silica nanostructures were achieved by selective removal of the ZnS core. The morphology, structure, and composition of the product were determined using powder X-ray diffraction (XRD), emission scanning electron microscopy (SEM), transmission electron microscopy (TEM), and Fourier transform infrared spectroscopy (FT-IR). The results demonstrated clearly that the pure ZnS nanoparticles are in a spherical form with the average size of 40 nm and correspond with zinc blend structure. The porous hollow silica nanoparticles obtained were exploited as drug carriers to investigate in vitro release behavior of amoxicillin in simulated body fluid (SBF). UV-visible spectrometry was carried out to determine the amount of amoxicillin entrapped in the carrier. Amoxicillin release profile from porous hollow silica nanoparticles followed a three-stage pattern and indicated a delayed release effect.

ABSTRACT. Hydrothermal method was used to synthesize pure ZnSe nanosphere materials. The effects of the reducing agent amount, the reaction time and temperature were investigated on the purity of ZnSe. Also, the effects of surfactants such as sodium dodecyl sulfate (SDS) (anionic) and cetyl trimethylammonium bromide (CTAB) (cationic) were studied on the morphology of ZnSe. The prepared nanospheres were characterized using XRD, SEM, TEM and UV-Vis spectroscopy. Through these techniques, it was found that the pure ZnSe nanoparticles have a zinc blend structure and in a spherical form with average diameter of 30 nm.

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In this contribution, porous hollow silica nanoparticles using inorganic nano sized ZnSe as template were prepared. The hydrothermal method was used to synthesize pure ZnSe nanospheres material. The ZnSe/SiO 2 core-shell nanocomposites were prepared using a simple sol-gel method successfully. The hollow silica nanostructures were achieved by selective removal of the ZnSe core. The morphology, structure and composition of the product were determined using powder X-ray diffraction (XRD), emission scanning electron microscopy (SEM), transmission electron microscopy (TEM) and Fourier transform infrared spectroscopy (FT-IR). The results demonstrated clearly that the pure ZnSe nanoparticles are in a spherical form with the average size of 30 nm and correspond with zinc blend structure. The porous hollow silica nanoparticles obtained were exploited as drug carrier to investigate in vitro release behavior of cefalexin in simulated body fluid (SBF). UV-Visible spectrometry was carried out to determine the amount of cefalexin entrapped in the carrier. Cefalexin release profile from porous hollow silica nanoparticles followed a three stage pattern and indicated a delayed release effect.

V2O5‐doped ZnO nanoparticles are synthesized by the wet incipient method from an aqueous suspension of ZnO nanoparticles (obtained from a solution of Zn(OAc)2, cetyltrimethylammonium bromide, and NaOH in EtOH at 70 °C for 2 h) and NH4VO3 at 70 °C, followed by calcination at 400 °C for 2 h.