The sun’s total radiation alone exceeds the world population’s entire energy consumption by 7.500 times and ignites secondary renewable energy sources. The end energy consumption buildings use for heating amounts to 28% of Germany’s total energy consumption. With the ongoing trend of digitalization and the transition of the German energy supply away from fossil fuels and the consequent political dependency, electric heat pumps and photovoltaic (PV) systems have become increasingly important to the discussion. This has led to an increasing demand for smart control strategies, especially for inert systems such as thermally activated building systems (TABS). This paper presents and analyses a weather predictive control (WPC) strategy using a validated thermodynamic simulation model. The literature review of this paper outlines that the current common control strategies are data intense and complex in their implementation into the built environment. The simple approach of the WPC uses future ambient temperature and solar radiation to optimize the control of the heating, cooling, ventilation, and sun protection system. The thermal comfort and energy demand evaluate the concept. We show that with a WPC for TABS, thermal comfort can improve without increasing the energy demand for the office building in the moderate climate of Munich. Furthermore, this paper concludes that the WPC works more effectively with more thermal mass. This simplified building control strategy promotes the European roadmap goal of climate neutrality in 2050, as it bridges the phenomenon of the performance gap.