The Caledonian Hecla Hoek succession in Ny Friesland, eastern Svalbard has been interpreted, for many decades, to be a continuous stratigraphic sequence. Early Palaeozoic and Neoproterozoic strata in its upper parts pass more or less conformably down into amphibolite facies rocks (Stubendorffbreen Supergroup) at depth. Recent isotopic age-determination and structural studies have indicated that the Stubendorffbreen succession is tectonostratigraphic and made up of at least three major thrust sheets. This paper provides new data from two meta-igneous units within the succession, the Bangenhuk and Instrumentberget gneisses. Both are granitoid sheets, consisting mainly of red, strongly lineated gneisses of monzogranitic composition; the Bangenhuk unit also contains some lenses of little deformed granitoids, as well as cross-cutting aplite dykes, amphibolitized dolerites and subordinate metasedimentary rocks. The latter are locally cut by granitoids. U-Pb

No abstract

No abstract

No abstract

Summary Aims:  To review the current knowledge of the benefits and risks of long‐term aspirin therapy for the prevention of cardiovascular disease. Methods:  Relevant articles published in English between 1996 and 2006 were obtained from the Current Contents Science Edition, EMBASE and MEDLINE databases. Results:  Secondary aspirin prophylaxis is effective in reducing the risk of ischaemic events in patients with cardiovascular disease. However, its utility in reducing primary ischaemic events is more controversial; it appears to reduce the incidence of ischaemic stroke, but increase the incidence of haemorrhagic stroke. Aspirin therapy can also lead to an increased risk of gastrointestinal ulcers, upper gastrointestinal bleeding and other haemorrhagic complications. Lower doses of aspirin are associated with a reduced risk of gastrointestinal side effects and are equally effective in reducing cardiovascular risk. Co‐therapy with non‐steroidal anti‐inflammatory drugs, clopidogrel or warfarin increases the risk of gastrointestinal side effects, while co‐therapy with proton pump inhibitors reduces it. Conclusions:  Both the benefits and risks need to be considered carefully when prescribing aspirin, particularly in primary prevention. Patients should be prescribed lower doses rather than higher doses of aspirin in line with prescribing guidelines. Co‐prescription of a proton pump inhibitors may be necessary in patients at high risk for upper gastrointestinal complications.