Background: Cystic fibrosis (CF) is associated with chronic respiratory disease and pancreatic insufficiency and results in the malabsorption of nutrients and intestinal inflammation. There is evidence that probiotic supplementation may impact the gastrointestinal and respiratory microbiota. This study aimed to categorize current evidence regarding the effects of supplementing with probiotics in CF patients on gastrointestinal and respiratory outcomes according to the type of intervention. Methods: The initial database search included all identified studies according to the recommendations of the Cochrane Collaboration, regardless of language, publication date or design. Studies were categorized by probiotic strain (Lactobacillus reuteri; Lactobacillus rhamnosus GG or a mix of strains); dosage (low dosage if <109 CFU [colony forming units] or high dosage if >109 CFU); and duration of intervention (1, 3, 6, or 12 months). Assessment of quality was performed based on the Cochrane risk of bias criteria and the Downs & Black checklist. Results: A total of 205 studies were identified; however, only 9 met the criteria for inclusion. The studies were considered to have a high risk of bias, hampering the possibility of performing a meta-analysis. Eighty percent of the studies (4 of 5) reported a positive result for intestinal inflammation, and another 4 studies (4 of 5) reported a positive result for pulmonary exacerbation frequency, regardless of the treatment approach. Conclusions: The present data indicate a promising future for probiotic use in cystic fibrosis, which has an impact on exacerbations and intestinal inflammation; however, further studies of standardized therapeutic interventions are required.

A systematic review was carried out aiming at analyzing daily physical activity during pregnancy and the outcomes of birth weight, prematurity, and intrauterine growth restriction. Of 52 articles indexed in Medline, 22 that showed better methodological quality were included. Among the 22 articles analyzed, only two did not detect a significant association between physical activity and the outcomes studied. There was large variation between the indicators of maternal physical activity, which included occupational, household, recreational and, all or some, locomotive activities. Among ten articles that measured total daily physical activity, only one article did not find any association. The results support the hypothesis that both excessive and insufficient physical activity impact negatively on pregnancy outcomes.

Introdução: A prática de atividade física tem sido incentivada por vários organismos nacionais e internacionais visando a promoção de saúde. Entretanto não existe consenso acerca da influência e da intensidade ótima de atividade física durante a gestação, possivelmente devido a dificuldades de mensuração e classificação do nível de atividade física através de questionários. Não se identificou qualquer estudo de validação de questionário de atividade física em gestantes no Brasil. O objetivo do presente estudo é analisar a reprodutibilidade e validade concorrente de um questionário de atividades físicas para gestantes. Métodos: Em amostra de 68 gestantes, no segundo trimestre de gestação foi realizada entrevista para aplicação do questionário, que foi repetida com aproximadamente uma semana de intervalo e no puerpério. No período entre as duas primeiras entrevistas, as mulheres utilizaram monitor de freqüência cardíaca (n=38). Resultados: As análises de reprodutibilidade foram adequadas com coeficientes de correlação intraclasse variando de 0,54 a 0,85. A análise das variáveis categóricas, com questões subjetivas e de autopercepção da atividade física, resultou em maior intervalo de coeficiente kappa com valores entre 0,29 e 0,76 entre a aplicação do questionário com uma semana de intervalo, e 0,08 a 0,70 comparado ao puerpério. As análises de validade conduziram a resultado satisfatório quanto à média das diferenças encontrada por intermédio do gráfico de Bland e Altman (1986) entre o questionário e o freqüencímetro. Entretanto, o intervalo da dispersão não se apresentou adequado, visto que variou em mais de sete horas para atividades leves e em quase onze horas por dia para atividades moderadas. As análises do presente estudo parecem assegurar a reprodutibilidade do questionário de atividade física para gestantes. No entanto, com relação à validação, a comparação com os resultados obtidos pelo freqüêncímetro não mostrou graus de concordância adequados.Palavras-chave: atividade cotidiana, confiabilidade, questionário, gravidez, cuidado pré-natal. ABSTRACTIntroduction: Physical activity practice has been encouraged by several national and international entities aiming health promotion. However, there is no consensus concerning the influence and optimal intensity of physical activity during pregnancy, probably due to difficulties to measure and classify the level of physical activity by questionnaires. It has not been identified any validation study of physical activity questionnaire on Brazilian pregnant women. The purpose of the present study is to analyze the reliability and concurrent validity of a physical activity questionnaire for pregnant women. Methods: A sample of 68 women in the second trimester of pregnancy has been interviewed by the elaborated questionnaire. Reliability was assessed after approximately a week and in the postpartum. The subjects used a heart rate monitor between the two first interviews (n=38). Results: Reproducibility analyses were adapted with interclass correlation coefficients var...

Objective: To develop a scientific consensus on nutrition in cystic fibrosis. Methods: Sixteen coordinators elaborated relevant questions on nutritional therapy in cystic fibrosis, which were divided into six sections: nutritional assessment, nutritional recommendations, nutritional intervention, dietary counseling, special situations and enzyme replacement, and gastrointestinal manifestations. Two to three specialists in the field were responsible for each section and obtaining answers formulated based on standardized bibliographic searches. The available literature was searched in the PubMed ® /MEDLINE database, after training and standardization of search strategies, to write the best level of evidence for the questions elaborated. Issues related to disagreement were discussed until a consensus was reached among specialists, based on the current scientific literature. Results: Forty-two questions were prepared and objectively answered, resulting in a consensus of nutritional therapy in cystic fibrosis. Conclusion: This work enabled establishing a scientific consensus for nutritional treatment of cystic fibrosis patients.