Cases 2 and 3.-September 13, several weeks after the first patient was seen, two brothers, aged 11 and 13, were brought to the hospital. Their symptoms and the clinical course of their disease were so nearly identical that a single report will suffice. Canvas slippers were dyed while on the feet, the dye being a substance that had been in the cellar about ten years. Soon after, the boys complained of a "pins and needles" sensation and numbness of the feet; two hours later they felt dizzy and weak, had a ringing in the ears, and fell in a stupor. They remained in a confused state about one hour. At this period they were admitted to the hospital : vomiting had set in; they were confused, unresponsive and dull; the skin and buccal membranes were deeply cyanosed ; respirations were rapid ; the lungs were clear ; the pupils were widely dilated and the heart rate 120 and 125, respectively; the action was rhythmic, the tones clear and the pulse of good volume. The temperature rose to 99.4 and 99.8, respectively. The feet were discolored with dye. After several hours, the symptoms began to subside, and on the following morning all the evidences of poisoning had disappeared. The urinalysis was negative in both patients ; blood examination made on the day following admission showed : a red count of 4,470,000 and 4,590,000 ; hemoglobin, 83 and 81 per cent, and a leukocyte count of 11,200 and 17,870, respectively, with a normal differential.