SARS-CoV-2 infection in children produces mild respiratory symptoms or no symptoms at all in most cases. Some pediatric patients develop a severe complication associated with high mortality, the multisystem inflammatory syndrome in children (MIS-C). In both scenarios, there are reports of neurological manifestations. This article aims to review the cases of pediatric patients with severe neurological issues and a coexisting positive SARS-CoV-2 test. A literature search was performed between March 2020 and May 2021. The results included the data from 41 studies, with 159 children with severe neurological manifestations, within an age range from 24 h to 17 years. The neurological disorders included 38 cases with stroke, 32 with encephalitis, 22 with encephalopathy, and 10 with Guillain–Barre syndrome. Sixty-five out of 159 cases with severe neurological manifestations were diagnosed with MIS-C. Direct neuroinvasion and the exaggerated immune response in some patients seem to be the most critical factors triggering these manifestations. Further research in the ongoing pandemic is needed to elucidate the precise mechanism.

Background. - The COVID-19 pandemic has forced nearly every nation around the world to implement border restrictions, some of which have prevented citizens from entering their own country. Restricting access to one’s own country was a burdensome intervention, but may have been necessary given the global emergency. Thus, the decision restrict citizens’ entry as a public health intervention warrants ethical analysis to determine its appropriateness. The focus of this paper is on the ethics of the 15-month border closure implemented in Trinidad and Tobago during the COVID-19 pandemic. Methodology. - Ethical analysis of the COVID-19 border closure in Trinidad and Tobago was done using a six-part ethical framework for public health. Discussion. - The ethical analysis highlights various areas of concern which question the justification for the border closure. The effectiveness, necessity and proportionality of the intervention were justified in the short-term, however, as benefits diminished over time, this did not result in appropriate policy changes. Continuous evaluation of the intervention throughout its use could have improved the balance of benefits and burdens thereby providing stronger ethical validation. Conclusion. - The COVID-19 border closure in Trinidad and Tobago brought substantial burdens upon its citizens without comparable benefits. Data from previous pandemics and the best available data during the current pandemic showed that effectiveness was limited to the initial months, after which it would have been unnecessary to maintain. Thus, the government’s decision to prolong the border closure for 15 months, well past its time of effectiveness, was not ethically justified from our analysis.