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Objective To investigate means of successful general practice amalgamation. Participants Three clusters of Sydney general practitioners who wished to amalgamate their solo or small group practices. Design Structured interviews were conducted with individual general practitioners and group meetings were held with members of each cluster. Result Successful amalgamation of solo/small practices starts with choosing compatible participants. Next, aims must be agreed upon and clearly spelt out. Commonly expressed goals of amalgamation were to reduce financial overheads, improve the range of patient services and increase opportunities for recreational and study leave. Financial and legal aid is essential for intending amalgamators. “Trial amalgamation” may be a safe option for those uncertain as to whether to commit themselves and their practices. Conclusions Practices can successfully amalgamate, but only with a group of like‐minded general practitioners who are willing to invest time to achieve mutually agreed objectives. Amalgamation is not always appropriate. (Med J Aust 1994; 161: 494‐496)