Purpose: To report ultraviolet-A (UV-A) light treatment in a patient with Acanthamoeba keratitis (AK). Methods: Interventional case report. A standard protocol for ultraviolet corneal therapy, with a power emission of 3 mW/cm² and a wavelength of 370 nm, was used. The protocol included an 8-nm bandwidth at a 54-mm distance measured with a collimation system of diodes as well as a protective shield of riboflavin in a case of documented AK. Results: A 54-year-old female patient with AK, showing no therapeutic response to a wide variety of topical antimicrobial agents and with a visual acuity of 20/400, was treated with UV-A therapy. The patient displayed a favourable response in the first 24 h after treatment, with improvement of symptoms, visual acuity (to 20/200) and biomicroscopy cornea with haze degree I. By the third week post-treatment, the patient was symptom-free. Her visual acuity was 20/30, and the affected cornea was clear. Five months after treatment, there had been no recurrence, and her vision was 20/20. Conclusions: Treatment with UV-A light was an effective therapy in this case of AK.

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Purpose: To report corneal stem cell allografts in a patient with a persistent epithelial defect as well as corneal melting and perforation due to severe ultraviolet light burn and thermokeratoplasty treatment for keratoconus. Methods: A 21-year-old female patient with corneal melting, perforation and a persistent epithelial defect in her left eye secondary to iatrogenic treatment for keratoconus, thermokeratoplasty and cross-linking was treated with penetrating keratoplasty, using a 9.0-mm diameter corneal graft and limbal stem cell allograft implants. At the end of the procedure, subtenonian injections of a combination of bevacizumab and triamcinolone were given. Results: The patient had a favorable outcome 48 h after surgery, with an improvement of symptoms and a complete corneal healing. By the third week after surgery, she had a best-corrected visual acuity of 20/60 and a clear corneal graft, which remained stable for the 9 months of follow-up. Conclusions: Treatment with limbal stem cell allografts and penetrating keratoplasty in a female patient with a large corneal defect and melting in her left eye was effective. Larger studies are warranted to explore the real impact of this procedure.

Introduction. Perinatal history is often underrated in ophthalmologic consultation. Nevertheless, an adequate interrogation of prenatal, perinatal, and postnatal issues may provide important information in order to establish an assertive diagnosis.Goltz syndrome or focal dermal hypoplasia is a rare multisystemic disease that involves the ectoderm, mesoderm, and endoderm. It is an X-linked dominant disease caused by the mutation of the PORCN gene. These patients present mainly vermiculate dermal atrophy, outpouchings of fat, telangiectasias, and hypopigmentation. They also present periorificial raspberry-like papilloma, dystrophic nails, sparse hair, abnormal teeth, split hand or foot, and ocular anomalies (microphthalmia). [1]. Three major findings of the skin/nails and one from limbs are necessary to make the clinical diagnosis. The case of a patient who was evaluated in two hospitals as a child and misdiagnosed with Goltz syndrome is described below.Sometimes when multiple findings are found on patient´s physical examination, quickly we think of a syndrome, however, there may be several diseases manifesting at the same time in the patient and not being entirely related to each other. A thorough interrogation provides the required background for medical reasoning, especially when the patient has been misdiagnosed in previous medical visits with other physicians. In this paper we substantiate this statement by describing a case of a 33-year-old woman who was misdiagnosed since childhood with Goltz syndrome, which delayed proper treatment.

El objetivo del estudio fue describir los resultados visuales y queratométricos de pacientes con queratocono sometidos a tratamiento con crosslinking (CXL). Método: Estudio retrospectivo de 277 ojos de 144 pacientes con queratocono progresivo que se sometieron a CXL. Se obtuvieron mediciones topográficas antes del procedimiento y 12 meses después. La agudeza visual corregida (AVC), la queratometría más plana (K1), la queratometría más curva (K2), el promedio de la queratometría (Kprom), el cilindro, el eje de K1, el eje de K2 y el valor paquimétrico del punto de la córnea más delgado fueron las variables evaluadas. resultados: A los 12 meses de seguimiento, los valores de AVC mejoraron. Hubo disminuciones estadísticamente significativas en K1 (p = 0,001), K2 (p = 0.000), eje de K1 (p = 0.000), eje de K2 (p = 0.004) y Kprom (p = 0.025). El análisis de correlación mostró que la AVC, la K1, la K2, el eje de K2, el Kprom y el cilindro preoperatorios, así como la K1, la K2, el Kprom y el cilindro posoperatorios, afectan significativamente la agudeza visual a los 12 meses de seguimiento. Conclusiones: El CXL es un tratamiento eficaz para mejorar la AVC a 1 año de seguimiento en el grupo de pacientes estudiados. Los valores de K preoperatorios y posoperatorios, y la AVC preoperatoria, se correlacionan de forma significativa con la AVC a los 12 meses de la aplicación del CXL.