Dedifferentiated liposarcoma (DDLS) is a high-grade sarcoma that usually arises from a well-differentiated liposarcoma, which most commonly presents as a retroperitoneal mass. DDLS involving the colon is extremely rare, and only a few cases have been reported. We present a case of a DDLS that was found in the cecum and adjacent mesentery. This aggressive sarcoma developed within six months based on computed tomography (CT) findings and initially presented as a perforated colon mass. The patient was taken for emergent exploratory laparotomy including right hemicolectomy with en bloc resection. There was no metastatic disease at time of presentation, but at three-month follow-up, CT scans demonstrated metastatic disease to the liver, lungs, and multiple peritoneal implants. This case highlights a rare form of colon cancer and its aggressive nature of progression.