Two quinazolinediones were crystallized and the molecular structures solved by monocrystal X-ray diffraction analysis. The title compounds include the only variation of the -OMe substituent at orto or meta positions of the aromatic ring. The results were contrasted with the analogous para substituted derivative allowing a complete structural comparison in order to see the substituent effect. The formation of different hydrogen bonding motifs was observed which are relevant to the design of supramolecular assemblies.