Paramagnetic NMR data contain extremely accurate long-range information on metalloprotein structures and, when used in the frame of integrative structural biology approaches, they allow for the retrieval of structural details...

When acquiring series of spectra ( T1,0.1emT2, CP buildup curves, etc.) on samples with poor SNR, we are usually faced with choosing between taking a few points with a large number of scans to maximize the SNR or more points with a smaller number of scans to maximize the information content. In this Letter, we show how low‐rank decomposition can be used to denoise a series of spectra, reducing the trade‐off between the number of scans and the number of experiments.