Due to its excellent programmability and biocompatibility, DNA molecule has unique advantages in cell surface engineering. Recent progresses provide a reliable and feasible way to engineer cell surfaces with diverse DNA molecules and DNA nanostructures. The abundant form of DNA nanostructures has greatly expanded the toolbox of DNA‐based cell surface engineering and gave rise to a variety of novel and fascinating applications. In this review, we summarize recent advances in DNA‐based cell surface engineering and its biological applications. We first introduce some widely used methods of immobilizing DNA molecules on cell surfaces and their application features. Then we discuss the approaches of employing DNA nanostructures and dynamic DNA nanotechnology as elements for creating functional cell surfaces. Finally, we review the extensive biological applications of DNA‐based cell surface engineering and discuss the challenges and prospects of DNA‐based cell surface engineering.

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DNA‐based cell surface engineering is a powerful tool for manipulating cell surface and cell behavior. Herein, we demonstrate that DNA‐based nanostructures as functional modules can be rationally integrated into cell surface to confer cells with new functions and control over cell behaviors. We believe that DNA‐based cell surface engineering will be capable of bringing more opportunities to cell surface engineering and cell‐based biomedical applications. For more information, see the Review by Q. Liu et al. (DOI: 10.1002/chem.202202070).