No abstract

A base-promoted cascade reaction of a-ketoester with benzylidene-malononitrile was developed under mild reaction conditions, which enabled the synthesis of polyfunctionalized 2-amino-3- cyano-4H-pyrans containing ester motifs at 6-position with good to excellent yields. These transformations not only construct various polyfunctionalized 4H-pyrans, which add a new member to the family of 4H-pyrans, but also provide an efficient approach for the synthesis of fully substituted 4Hpyran derivatives