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Based on the outcome-based education (OBE) and by combining with the instructional objectives of Organic Chemistry in USTC and Learning Pyramid, we have designed an online and offline blended "PTDCA" teaching method of guided preview (P), precise teaching (T), mutual discussion (D), demonstrative comments (C) and whole process assessment (A). This teaching method is student-centered and achievement-oriented, and could guide students to improve their learning initiative and ability to solve practical problems. The method has been applied to practical teaching, achieved good teaching results and achieved the expected goal.

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