Background Dermocosmetic products are often used to maintain or enhance the tolerance and effectiveness of medical anti‐acne therapies. Recent discoveries about the pathophysiology of acne‐prone skin indicate that skincare products may help maintain homeostasis around the sebaceous gland progenitor cells, thereby preventing microcomedone formation. Aims To evaluate the tolerance and effectiveness of a dermocosmetic product containing Silybum marianum fruit extract (SMFE) in adolescents and young adults with acne‐prone skin. Patients/Methods This real‐life, international, observational, multicenter study was conducted in patients aged 12–25 years with mild‐to‐moderate acne. Patients (N = 4230) used the product twice daily for 8–12 weeks, either alone before (“initial group”) or after an anti‐acne therapy (“maintenance group”), or in association with their usual prescribed anti‐acne therapies (“association group”). The tolerance, effectiveness, and cosmetic properties of the product were assessed. Patient quality of life (QoL) was also evaluated. Results Dermatologists rated the tolerance of the product as “good” or “very good” in about 95% of the patients and the effectiveness of the product as “effective” or “highly effective” in about 80% of the patients, with a significant reduction in the mean global evaluation of acne (GEA) grade (−36% ± 39%, p < 0.0001) at study end. The QoL of most patients (80%) improved by the end of the study, and the majority (79% to 94%) appreciated the cosmetic properties of the product. Overall, the product was a clinical success in >84% of patients. Conclusions This dermocosmetic product can be used by adolescents and young adults with acne‐prone skin to limit the initial or chronic use of medical anti‐acne therapies.

The vermilion of the human lip, covered by a skinny epithelium with little melanin, is quite susceptible to damage from ultraviolet (UV) radiation exposure. However, commercial sunscreen filters and indelible dyes used in lipsticks can cause health hazards after percutaneous absorption or accidentally oral administration. Inspired by plant pigmentation as natural filters to protect themselves against overexposure to UV, safer bio-based sunscreens of cellulose enveloped with anthocyanin (AN) were developed using bionic design. Cellulose nanocrystals (CNC), derived from acid hydrolysis of cellulose, reinforced enhancement of UV absorption and shielding properties of AN. This innovation addresses the issue that naturally sourced UV filter application to sunscreen does not achieve a desired sun protection factor (SPF) value because of the low specific extinction value (E1,1). We also stated that the diverse formula of anthocyanin sunscreen lipsticks with CNC exhibited 10 times more SPF value than AN alone. Furthermore, they possess competitive benefits such as pleasing texture, superior adhesion, impermeable, nonphototoxicity, ease of application, and removal. This work provides a promising proof-of-concept for studying the features of natural sunscreens in the design of simple, safe, efficient, and green sunscreens.