Systemic lupus erythematosus (SLE) is an autoantibody-related disease that affects multiple organs. Stercoral colitis (SC) is a rare type of inflammatory colitis with a high mortality rate. Here, we report the first case of pediatric-onset lupus in a case complicated by stercoral colitis. We also conducted a literature review of patients with SC under 30 years old to provide useful clues for rapid diagnosis at a young age. A 28-year-old female with a history of lupus and neuropsychiatric SLE was admitted with severe abdominal pain. She was found to have stercoral colitis during surgery. Two years later, the patient underwent Hartman's operation due to ischemia of the colon. In addition, 10 patients younger than 30 years old with a diagnosis of SC were analyzed based on clinical presentation, physical examination, laboratory exam, imaging and treatment. All cases had a favorable outcome without mortality. Stercoral colitis is a rare but lethal complication, emphasizing the importance of a multidisciplinary approach. Differential diagnosis should include stercoral colitis for patients with SLE developing unexplained sharp abdominal pain.

RATIONALE: Atopic eczema and food allergy are common during the first 2 years of life. The relationship between eczema onset after infancy and allergen sensitizationand atopic diseases was investigated. METHODS: We investigated 186 children followed up regularly for 4 years in a birth cohort study. Early-onset eczema was defined to occur symptoms before age of 2. Specific IgE antibodies against food (egg white, milk, and wheat) and inhalant allergens (mite) were measured at 6 months as well as 1, 1.5, 2, 3 and 4 years of age. The associations between onsets of eczema and atopic indices were assessed. RESULTS: A significantly higher prevalence of sensitization to food, especially milk was found in children with early-onset eczema compared to children without eczema at age 1, 1.5, 2, 3 and 4. A significantly higher number of eosinophils was found in children with early or late-onset eczema compared to children without eczema at age of 1.5 years. Both early and late-onset eczema were not only significantly associated with higher prevalence of allergic rhinitis at 2, 3, and 4 years of age, but also asthma at age 2. Furthermore, early-onset eczema appeared to show a significantly increased risk of allergic rhinitis [odds ratio (OR), 3.71; 95% confidence interval (CI), 1.37-10.02; P 5 0.010] and asthma (OR, 3.80; 95% CI, 1.12-12.85; P 5 0.032) at an age of 4 years. CONCLUSIONS: Early-onset eczema appears not only to be associated with an increase in the prevalence of milk sensitization but also the risk of rhinitis and asthma in early childhood.

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