The aim of this study was to evaluate whether the expression of annexin A1 (ANXA1) is associated with the progression of cervical neoplasia. ANXA1 expression was examined by immunohistochemistry in paraffin-embedded cervical tissue samples (n = 234), comprising 52 samples of normal cervical epithelia, 30 of cervical intraepithelial neoplasia (CIN) I, 27 of CIN II, 32 of CIN III, and 93 of invasive squamous cell carcinoma (ISCC). ANXA1 expression was strong in normal cervical squamous epithelium and significantly reduced with increasing progression of cervical neoplasia. Moreover, a close association was observed between ANXA1 expression and tumour cell differentiation in ISCC. These preliminary results indicate that ANXA1 may be an effective candidate for detecting CIN lesions and for evaluating tumour cell differentiation in squamous cell carcinoma of the cervix.

The changes of the intracellular inositol-1,4,5-triphosphate (IP3) associated with the expression of the interleukin 2 receptor (IL-2R) were studied. In resting lymphocytes, IL-2 did not alter intracellular concentration of IP3, but Con A caused an increase in IP3 by 45%. In IL-2 sensitive T cells, which expressed IL-2R by 83%, the change of intracellular IP3 was dependent upon IL-2 concentration. The IP3 increased at IL-2 concentrations of 10 and 50 U/ml, and the maximal response of 60% was found at the concentration of 50 U/ml. At IL-2 concentration of 100 U/ml no increase in IP3 was observed. After binding of anti-Tac McAb to IL-2R of T lymphocytes the increase in IP3 at IL-2 concentrations of 10 and 50 U/ml was significantly attenuated. It has been suggested that IL-2 could induce the changes of intracellular IP3 of the human peripheral blood T cells, which is related to the IL-2 concentrations incubated with T cells and the expression of IL-2R on T lymphocyte.

Type 2 diabetes is a disease caused by genetic and environmental factors that endanger public health [1]. At present, hereditary factors are still unknown, and it has been confirmed that type 2 diabetes is closely related to a highcalorie diet, lack of exercise, obesity, etc. [2,3]. It has been reported that the overall incidence of diabetes in Chinese adults is about 11.6%, and the prediabetes incidence in these people is 50.1%. However, the awareness rate of