No abstract

Using stem cells plus autologous fibrin glue as the carrier may accelerate new bone regeneration.

Angiogenesis and hypoxia are reported to correlate with tumor aggressiveness. In this study, we investigated the potential of optically measured total hemoglobin concentration (THC) and blood oxygen saturation (StO 2 ) as a quantitative measure of angiogenesis and hypoxia in oral lesions with an immunohistochemical comparison. 12 normal subjects and 40 oral patients (22 oral squamous cell carcinoma (SCC), 18 benign/premalignant lesions including 11 verrucous hyperplasia (VH) and 7 hyperkeratosis/parakeratosis (HK)) were studied. The results showed that the THC measurement was consistent with vascular endothelial growth factor (VEGF) and microvessel staining in the stromal area, but StO 2 was not associated with HIF-1α. We observed inflammation induced neovascular formation in the stromal area of VH and HK that were likely attributed to higher-than-control THC and StO 2 and resulted in no difference in optical measurements between all lesions. However, we found that in majority of SCC, the ratio of THC and StO 2 levels between lesions and the surrounding tissues provide potential distinguishing characteristics from VH, which are not visually differentiable from SCC, with a sensitivity, specificity, and accuracy of 91%, 68%, and 76%, respectively.

Our proposed classification may help clinicians to identify patients with gingival SCC who present with more advanced disease status.

Background/purpose: The purpose of this study was to determine the prevalence of obstructive sleep apnea (OSA) in patients with squamous cell carcinoma (SSC) of the tongue after primary surgical resection and to correlate the presence of OSA with the occurrence of obstructive apnea in this patient population. Materials and methods: This was a retrospective study of 26 Taiwanese patients, 24 males and two females, aged 37e71 years, after surgical resection of SSC of the tongue. Patients who had a follow-up after treatment of 6 months to 11 years were eligible for inclusion. During the posttreatment period, the occurrence of OSA was determined in these patients. Overnight polysomnography (PSG) was used to determine the apneaehypopnea index (AHI). Patients were considered to have OSA if the AHI value was >5. Results: Patients with an AHI value of <5 showed a mean body mass index (BMI) of 22.8 kg/m 2 , while those with an AHI value of >5 showed a mean BMI of 28.3 kg/m 2 . The BMI distribution between patients with AHI value of <5 and those with AHI values of >5 was statistically significant (P Z 0.018). Using the definition of clinically significant sleep apnea as AHI > 5, 14 of 26 patients (53.85%) had clinical OSA. The OSA and non-OSA groups showed no statistical significance in terms of age, tumor size, tongue ablation, neck dissection [method?], or wound reconstruction methods. Conclusion: Incidence of OSA in the patient population with SSC of the tongue was found to be significantly higher than that in the general population. The limitations of this study were the Journal of Dental Sciences (2012) 7, 245e249 relatively small patient sample size and no presurgical PSG record being obtained from the patients to compare the sleep quality before and after cancer therapy.