Numerical investigation of the compressible flow past a wavy cylinder was carried out using large-eddy simulation for a free-stream Mach number M∞ = 0.75 and a Reynolds number based on the mean diameter Re = 2 × 105. The flow past a corresponding circular cylinder was also calculated for comparison and validation against experimental data. Various fundamental mechanisms dictating the intricate flow phenomena, including drag reduction and fluctuating force suppression, shock and shocklet elimination, and three-dimensional separation and separated shear-layer instability, have been studied systematically. Because of the passive control of the flow over a wavy cylinder, the mean drag coefficient of the wavy cylinder is less than that of the circular cylinder with a drag reduction up to 26%, and the fluctuating force coefficients are significantly suppressed to be nearly zero. The vortical structures near the base region of the wavy cylinder are much less vigorous than those of the circular cylinder. The three-dimensional shear-layer shed from the wavy cylinder is more stable than that from the circular cylinder. The vortex roll up of the shear layer from the wavy cylinder is delayed to a further downstream location, leading to a higher-base-pressure distribution. The spanwise pressure gradient and the baroclinic effect play an important role in generating an oblique vortical perturbation at the separated shear layer, which may moderate the increase of the fluctuations at the shear layer and reduce the growth rate of the shear layer. The analysis of the convective Mach number indicates that the instability processes in the shear-layer evolution are derived from oblique modes and bi-dimensional instability modes and their competition. The two-layer structures of the shear layer are captured using the instantaneous Lamb vector divergence, and the underlying dynamical processes associated with the drag reduction are clarified. Moreover, some phenomena relevant to the compressible effect, such as shock waves, shocklets and shock/turbulence interaction, are analysed. It is found that the shocks and shocklets which exist in the circular cylinder flow are eliminated for the wavy cylinder flow and the wavy surface provides an effective way of shock control. As the shock/turbulence interaction is avoided, a significant drop of the turbulent fluctuations around the wavy cylinder occurs. The results obtained in this study provide physical insight into the understanding of the mechanisms relevant to the passive control of the compressible flow past a wavy surface.

We have previously demonstrated that the NKR repertoire is profoundly disrupted by SHIP deficiency. This repertoire disruption is characterized by receptor dominance where inhibitory signals from 2B4 repress killing of complex targets expressing MHC class I and activating ligands. In this study, we examine the molecular basis of receptor dominance in SHIP−/− NK cells. In this study, we show that in SHIP−/− NK cells there is a pronounced bias toward the 2B4 long isoform. We have also characterized signaling molecules recruited to 2B4 in SHIP−/− NK cells. Interestingly, we find that ∼10- to 16-fold more Src homology region 2 domain-containing phosphatase 1 (SHP1) is recruited to 2B4 in SHIP−/− NK cells when compared with wild type. Consistent with SHP1 overrecruitment, treatment with sodium orthovanadate or a novel inhibitor with micromolar activity against SHP1 restores the ability of SHIP−/− NK cells to kill Rae1+ RMA and M157+ targets. These findings define the molecular basis for hyporesponsiveness by SHIP-deficient NK cells.

Numerical investigation of the compressible flow past an 18% thick circular-arc aerofoil was carried out using detached-eddy simulation for a free-stream Mach number M∞ = 0.76 and a Reynolds number Re = 1.1 × 107. Results have been validated carefully against experimental data. Various fundamental mechanisms dictating the intricate flow phenomena, including moving shock wave behaviours, turbulent boundary layer characteristics, kinematics of coherent structures and dynamical processes in flow evolution, have been studied systematically. A feedback model is developed to predict the self-sustained shock wave motions repeated alternately along the upper and lower surfaces of the aerofoil, which is a key issue associated with the complex flow phenomena. Based on the moving shock wave characteristics, three typical flow regimes are classified as attached boundary layer, moving shock wave/turbulent boundary layer interaction and intermittent boundary layer separation. The turbulent statistical quantities have been analysed in detail, and different behaviours are found in the three flow regimes. Some quantities, e.g. pressure-dilatation correlation and dilatational dissipation, have exhibited that the compressibility effect is enhanced because of the shock wave/boundary layer interaction. Further, the kinematics of coherent vortical structures and the dynamical processes in flow evolution are analysed. The speed of downstream-propagating pressure waves in the separated boundary layer is consistent with the convection speed of the coherent vortical structures. The multi-layer structures of the separated shear layer and the moving shock wave are reasonably captured using the instantaneous Lamb vector divergence and curl, and the underlying dynamical processes are clarified. In addition, the proper orthogonal decomposition analysis of the fluctuating pressure field illustrates that the dominated modes are associated with the moving shock waves and the separated shear layers in the trailing-edge region. The results obtained in this study provide physical insight into the understanding of the mechanisms relevant to this complex flow.

Abstract