We do not know the clinical and prognostic factors that influence the survival of patients with gastric signet ring cell carcinoma (SRC). Therefore, a retrospective review was undertaken of 219 patients with SRC who had undergone gastrectomy between January 2009 and December 2012 in our hospital. Patient age, sex, TNM stage, vessel carcinoma embolus, perineural invasion, tumor site and operation type, postoperative chemotherapy, and five-year overall survival were recorded and evaluated. In our study, 93 cases (42.5%) were signet ring cell carcinoma only, and 126 cases (57.5%) were signet ring cell carcinoma coexisting with other components (such as adenocarcinoma or mucus adenocarcinoma). Eighty-three patients were female, 136 were male, 46 occurred at the gastroesophageal junction (21.0%), 63 at the fundus/body (28.8%), 80 were antrum/pylorus (36.5%), and 30 were whole stomach (13.7%). The prognosis of gastric antrum/ pylorus cancer was the best (P < 0.05). There were 133 patients (60.7%) with stage III, and the single factor analysis showed that the earlier the stage, the better the prognosis. The overall five-year survival rate was 30.1% in all patients. One-hundred and 41 patients (64.4%) received D2 radical surgery, 64 (29.2%) received D1 radical operation, and 14 (6.4%) received palliative resection, and the patients who received D2 had the best overall survival (P < 0.05). The survival time of the paclitaxel-based regimen in postoperative adjuvant chemotherapy tended to be prolonged. There was no statistical difference in overall survival between the percentage of signet-ring cells and sex. In summary, age, tumor stage, and surgical resection combined with D2 lymphadenectomy were independent prognostic factors for SRC. Adjuvant chemotherapy with a paclitaxel-based regimen may improve the survival of patients with SRC.

Objective: This study aimed to investigate the clinical efficacy of statins in the prevention and treatment of coronary heart disease. Methods: A total of 130 cases of patients with coronary heart disease were selected as research objects. These patients were admitted in our hospital from February 2015 to January 2017. All patients with coronary heart disease were randomly divided into two groups as follows: control group (n=65), undergoing the conventional therapy of coronary heart disease; observation group (n=65), undergoing the conventional therapy+pravastatin/simvastatin. Finally, the efficacies, blood lipid improvement results, treatment satisfaction survey results, and adverse reactions of patients were compared between the two groups. Results: The efficacy of patients with coronary heart disease in the observation group was significantly increased (98.46%) compared with that in the control group (80%) (P<0.05). The blood lipid of patients with coronary heart disease in the observation group was also significantly improved (P<0.05). The treatment satisfaction survey results of patients with coronary heart disease in the observation group were also significantly improved (98.46%) compared with that in the control group (84.62%) (P<0.05). Furthermore, the incidence of adverse reactions of patients with coronary heart disease in the observation group was significantly reduced (3.08%) compared with that in the control group (18.46%) (P<0.05). Conclusion: During the prevention and treatment of coronary heart disease, the rational application of statins can improve the efficacy, blood lipid level, therapy satisfactions, and therapeutic safety so as to alleviate the coronary heart disease and improve the overall efficacy.