This is the first report of HF-related remodeling of outward K+ currents in murine LV. Similar to humans, disease-related remodeling occurs differentially across the murine ventricular wall, leading to loss of the native gradient of repolarization. Together with slowed recovery from inactivation, these alterations likely promote abnormal impulse conduction, a major proarrhythmic mechanism.

The COVID-19 pandemic provided a commercial opportunity for traders marketing a range of ultraviolet (UV) radiation products for home-use disinfection. Due to concerns about the efficacy of such products and the potential for harmful levels of UV exposure to people, a range of products were purchased from on-line trading platforms. Spectral irradiance measurements were carried out to determine whether the products could be effective against the SARS-CoV-2 virus and whether they were likely to exceed internationally agreed exposure limits. It was concluded that many of the devices were not effective and many of those that were potentially effective presented a risk to users.

No abstract

The advent of deep learning has brought in disruptive techniques with unprecedented accuracy rates in so many fields and scenarios. Tasks such as the detection of regions of interest and semantic features out of images and video sequences are quite effectively tackled because of the availability of publicly available and adequately annotated datasets. This paper describes a use case scenario with a deep learning models' stack being used for crowd behaviour analysis. It consists of two main modules preceded by a pre-processing step. The first deep learning module relies on the integration of YOLOv5 and DeepSORT to detect and track down pedestrians from CCTV cameras' video sequences. The second module ingests each pedestrian's spatial coordinates, velocity, and trajectories to cluster groups of people using the Coherent Neighbor Invariance technique. The method envisages the acquisition of video sequences from cameras overlooking pedestrian areas, such as public parks or squares, in order to check out any possible unusualness in crowd behaviour. Due to its design, the system first checks whether some anomalies are underway at the microscale level. Secondly, It returns clusters of people at the mesoscale level depending on velocity and trajectories. This work is part of the physical behaviour detection module developed for the S4AllCities H2020 project.

Description of case: We report a case of Tropheryma whipplei endocarditis, a rare cause of blood-culture-negative infective endocarditis (BCNIE). Due to its rarity and lack of availability of diagnostic tests in district hospitals, the diagnosis remains challenging. The objective of this case report is to increase physician awareness of this pathogen. A 61-year-old man presented to the Emergency Department with central chest pain at rest. A 12-lead ECG demonstrated ST- segment depression in V4-V6 leads, and his serial troponin levels were raised. He was commenced on treatment for acute coronary syndrome and transferred to the Coronary Care Unit. An echocardiogram showed a 15mm x 15mm vegetation in the aortic valve with mild aortic regurgitation. His initial microbiology workup, which included two sets of blood cultures (pre-antibiotics), MRSA screen & COVID-19 PCR, was negative. He was transferred to a cardiothoracic centre four days later. Pre-operative CT coronary angiogram showed severe three vessel coronary artery disease. He underwent triple coronary artery by-pass grafts and tissue aortic valve replacement. During early post-op recovery, he had fever episodes and an elevated C-reactive protein of 280 mg/L but normal white cell counts. He was treated with intravenous Tazocin for hospital-acquired pneumonia and discharged on doxycycline. Two weeks post-discharge, he had a positive 16S/18S PCR for Tropheryma whipplei on molecular analysis of the aortic valve. He was treated for Whipples endocarditis with a 4-week course of IV Ceftriaxone, followed by a 12-month course of oral Cotrimoxazole. The patient has reported doing well since the surgery. Discussion: Molecular assay with PCR of the heart valve is the mainstay of diagnosing Whipple’s endocarditis. There have been 5 previously reported cases of Whipple’s endocarditis in the United Kingdom in our knowledge. It is likely under-reported because of a reliance on tissue diagnosis. Preceding intestinal manifestations and arthralgia should raise its clinical suspicion for timely workup. Physician awareness of Whipple’s Endocarditis is paramount in investigating for this pathogen.