Total stressed blood volume (SBV T ) and arterial elastance (E a ) are two a potentially important, clinically applicable metrics for guiding treatment in patients with altered hemodynamic states. Defined as the total pressure generating blood in the circulation, SBV T is a potential direct measurement of tissue perfusion, a critical component in treatment of sepsis. E a is closely related to arterial tone thus provides insight into cardiac efficiency. However, it is not clinically feasible or ethical to measure SBV T in patients, so a three chambered cardiovascular system model using measured left ventricle pressure and volume, aortic pressure and central venous pressure is implemented to identify SBV T and E a from clinical data.SBV T and E a are identified from clinical data from six (6) pigs, who have undergone clinical procedures aimed at simulating septic shock and subsequent treatment, to identify clinically relevant changes. A novel, validated trend analysis method is used to adjudge clinically significant changes in state in the real-time E a and SBV T traces. Results matched hypothesised increases in SBV T during fluid therapy, with a mean change of +21% during initial therapy, and hypothesised decreases during endotoxin induced sepsis, with a mean change of -29%. E a displayed the hypothesised reciprocal behaviour with a mean changes of -12% and +30% during initial therapy and endotoxin induced sepsis, respectively. The overall results validate the efficacy of SBV T in tracking changes in hemodynamic state in septic shock and fluid therapy.

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