Learning is the major human activity which can make people to accommodate the environment or the society better. The effectiveness of learning is one important research issue in orange technology. The learning effectiveness of nurse education is more important than the other types of educations. In this paper, we proposed a work which develops a simulationbased digital courseware for intramuscular injection training in nurse education, to improve the learning effectiveness of practical nursing care training. The design of courseware is guided by the constructivism. In addition, the scenario simulation and game are involved to enhance the learning motivation. Moreover, the course has been successfully applied on the nursing students in Taiwan.