Background/Aims: MicroRNAs (miRNAs) have a key role in carcinogenesis and cancer development, but the role of miRNAs in the progression of esophageal cancer (EC) remains unclear. Methods: The TE-1 and Eca-109 EC cell lines were used. The expression of miR-491 and candidate gene TPX2 in EC samples (n=99) were detected by RT-PCR. The cells invasive ability was determined by transwell assay. The luciferase reporter assay was used to confirm the regulation mechanism. Results: A decreased expression of miR-491 was detected in the EC clinical samples compared with the corresponding adjacent tumor tissues. Aberrant expression of miR-491 regulated cells invasion and EMT markers. Furthermore, we verified that TPX2 was a target gene of miR-491. Conclusions: miR-491 may play a critical role in EC.

No abstract

No abstract

This paper introduces the features of using co-rotating vortex generators for controlling boundary layer and flow field in the inlet without flow separation. The principles of the arrangements of the blades and selection of constructional parameters of the generators that are applied to create the transverse flow between the high and low pressure regions and to reduce the secondary flow losses are analysed. The experimental results show that when the appropriate parameters of the co-rotating vortex generators are chosen for the inlet subsonic diffuser with apparent high and low pressure regions, not only the nonuniformity of the flow field is greatly improved but also the dynamic performance of the flow at exit is slightly improved.