Numerous studies have reported on the roles of genetic factors in the development of depression in adolescents and young adults. However, there are few systematic reviews that update our understanding of adolescent depression with the biological findings identifying the roles of gene expression and/or polymorphism(s). This review systematically summarized the findings that clearly identified the contribution of a gene to the risk of depression in adolescents between the ages of 10 and 19 years old and young adults between the ages of 20 and 25 years old. Data were obtained through searching PubMed, Embase, and Web of Science. A total of 47 studies on early adolescence and three studies on young adults were included in the current review. Most articles studied genes in the serotonergic system (n = 26), dopaminergic system (n = 3), and the Brain-derived neurotropic factor (BDNF) gene (n = 12). 92.3% of studies (24/26) identified positive associations of 5-HTTLPR polymorphism with depressive illness or depressive symptoms. 83.3% of studies (10/12) found positive association between BDNF Val66Met genotype and adolescent depressive symptoms. More studies should be conducted on the 18 genes reported in a few studies to clarify their roles in the risk for adolescent depression.

SUMMARYThe hMSH5 C85T polymorphism (encoding hMSH5 P29S) is associated with male infertility and radiation-induced apoptotic response. To date, however, the potential association of hMSH5 C85T polymorphism with DNA damage accumulation in spermatozoa of cancer patients treated with radiotherapy is largely unknown. We investigated hMSH5 C85T allele and genotype frequencies, routine semen analysis and sperm DNA Fragmentation Index (DFI) in 113 testicular germ cell tumor (TGCT) patients before and after radiotherapy. The hMSH5 C85T allele is not associated with the occurrence of TGCT. However, in comparison with the CC genotype, TGCT patients with the CT + TT genotypes showed significantly altered sperm counts, sperm morphology and DFI after radiotherapy. Finally, the results of the DSB repair assay demonstrated that hMSH5 P29S could enhance radiotherapy-induced DNA damage by unleashing error-prone non-homologous end joining. Together, our studies indicate that the hMSH5 C85T variation could have an impact on the severity of radiotherapy-provoked long-term side effects through compromising the repair of radiationinduced DNA lesions.

With the development of power plant units of higher capacity and with improved parameters, the proportion of high-capacity units for generating power has increased; this requires large capacity units to take responsibility for power-grid peak shaving. When the boiler operates at low loads, the working fluid in the boiler water wall tubes is subjected to high heat flux in the furnace, which can cause heat transfer deterioration, tube overheating or even leakage. Therefore, it is particularly important to study the reliability of the boiler hydrodynamic cycle during peak shaving (low load operation). This study takes a 1000 MW ultra-supercritical single-reheat Π type boiler with single furnace and double tangential firing as the research object. A furnace Computational Fluid Dynamics (CFD) and hydrodynamic coupling analysis model is established and verified according to the actual operating conditions on site. The calculation results show that the simulated value is in good agreement with the actual operating value. Therefore, the model established in this study can reflect the real situation of the on-site furnace to a certain extent, and has high reliability. Based on the fitting results, the causes of steam temperature deviation of the boiler water wall are analyzed, and measures to reduce the deviation are proposed to provide a necessary basis for power plant operation and boiler design.