Rationale: Guillain-Barré syndrome (GBS) is a rare autoimmune disease. Patients with cervical malignancies and intracranial meningiomas after the course of GBS are even rarer. There are no relevant reports at present. Patient concerns: We report a patient who developed cervical cancer (CC) and intracranial meningioma simultaneously after the course of GBS. Diagnoses: The history, pelvic enhanced magnetic resonance imaging (MRI) and pathology confirmed cervical squamous cell carcinoma, and the head enhanced MRI confirmed meningioma. Intervention: After multi-disciplinary team, the patient received head stereotactic radiosurgery for meningioma and radical radiotherapy for CC. Outcomes: The follow up for 1 year after treatment revealed a complete remission of the cervical tumor, stable disease of the meningioma, and no signs of GBS recurrence. Up to now, the general condition of the patient is acceptable and the curative effect is satisfactory. Lessons: This case report aims to improve the oncologists’ understanding of malignant tumors with rare autoimmune diseases and provide treatment reference for similar diseases in the future.