I The rabbit has recently been found to be susceptible to the strains now cultivated in laboratory animals.

No abstract

With the return of the circulation, dilation of the pericellular lymph space and slight swelling of the cell body occurs, disappearing as recovery progresses. Chromatolysis, as evidenced by poor affinity for stains, clumping, diffuse staining, and breaking into dust-like particles, induced by anæmia, is not necessarily fatal. Death of the cell is not shown histologically when tissue is removed and fixed immediately after the experiment. Some time must elapse for the detection of the vacuolation, displacement of the nucleus and solution of the chromatic substance, indicative of profound changes. Neurones from different regions as well as neurones of the same region differ in degree of resistance to anæmia. The small pyramidal cells are the most susceptible, and then come the Purkinje cells, cells of the medulla oblongata, retina, cervical cord, lumbar cord, spinal ganglia and, most resistant of all, the sympathetic ganglion cells. Failure to resuscitate animals after anæmia of the central nervous system is probably due to the destruction of many of the cells of the vital centers (vaso-motor and respiratory) which do not have histological peculiarities by which they may be defined. Death, however, of a few cells of any center does not necessarily mean the total loss of function of that center, since the remaining cells may be sufficient to discharge the function of the center.

A case of giant condyloma acuminatum of the scrotum is reported. It was initially diagnosed as a low grade squamous carcinoma. This neoplasm is closely related to Human Papillomavirus, mainly HPV 6 and HPV 11, and may be clinically indistinguishable from squamous carcinoma. The histological appearance is benign, however, its clinical behaviour is similar to verrucous carcinoma. A review of previously reported cases has been undertaken. The true significance of this lesion and management are discussed. Early aggressive therapy is recommended.