Antisocial personality disorder (ASPD) is a common behavioral pattern that causes sufferers to ignore or violate the rights of others. Though its cause is still unclear, previous studies have shown that childhood maltreatment is closely related to ASPD. The NOS1AP gene is associated with various neuropsychiatric diseases, but a linkage between it and ASPD has not yet been discovered. This study recruited ASPD and non‐ASPD male subjects who had committed violent crimes from a prison in Nanjing, China. By comparing the two groups' genotypes, allele frequencies, and histories of childhood abuse, we explored the interaction between the NOS1AP gene and childhood maltreatment on the pathogenesis of ASPD. The results showed that polymorphism rs945713 in the NOS1AP gene was associated with ASPD and furthermore that this SNP may be involved in regulating the effect of childhood abuse on ASPD. This study found that childhood trauma increases the risk of ASPD in violent adult male inmates; for prisoners with ASPD, it is critical to pay attention to their childhood trauma and take early psychological intervention.

Background: NSSI is a common behavior among psychiatric patients that is easily overlooked and often brings serious consequences. The current literature is limited to certain groups of people and uses different diagnostic criteria, so the prevalence of this behavior is unknown. The aim of this study was to investigate the prevalence of NSSI in patients with mental disorders in China using DSM-5 diagnostic criteria. Methods: A two-week multi-center cross-sectional survey was conducted in 15 specialized psychiatric hospitals or general hospitals (including outpatients and inpatients) from 14 cities in 8 provinces of China. DSM-5 diagnostic criteria were used to investigate the presence of NSSI behavior in all patients with mental disorders who came to their psychiatry departments. Findings: A total of 3,298 patients with mental disorders were included in the study. The prevalence of NSSI was 6.8% in outpatients and 6.5% in inpatients. There were signi cant differences in the prevalence of NSSI among different age groups (χ2=187.461, p<0.000). The highest prevalence of NSSI behavior was found in adolescents aged 10-19 years (14.3%), followed by young adults aged 20-29 years (7.0%). The prevalence of NSSI behavior in females was signi cantly higher than in males (P=16.9 %, χ2=31.322, p<0.000) (P=19.6 %, χ2=11.723, p=0.001) (P=5.9 %, χ2=6.094, p=0.014) ((P=7.7 %, χ2=14.472, p<0.000). The prevalence of NSSI behavior in patients with Personality disorders was signi cantly higher than in any other diagnostic group (P=46.7%, χ2=195.239, p<0.000). Interpretation: The prevalence of NSSI in patients with mental disorders is high, especially in adolescents. Therefore, it is necessary to inform patients and medical workers how to effectively treat and manage NSSI in order to reduce its occurrence.

Background: NSSI is a common behavior among psychiatric patients that is easily overlooked and often brings serious consequences. The current literature is limited to certain groups of people and uses different diagnostic criteria, so the prevalence of this behavior is unknown. The aim of this study was to investigate the prevalence of NSSI in patients with mental disorders in China using DSM-5 diagnostic criteria. Methods: A two-week multi-center cross-sectional survey was conducted in 15 specialized psychiatric hospitals or general hospitals (including outpatients and inpatients) from 14 cities in 8 provinces of China. DSM-5 diagnostic criteria were used to investigate the presence of NSSI behavior in all patients with mental disorders who came to their psychiatry departments. Findings: A total of 3,298 patients with mental disorders were included in the study. The prevalence of NSSI was 6.8% in outpatients and 6.5% in inpatients. There were significant differences in the prevalence of NSSI among different age groups (χ2=187.461, p<0.000). The highest prevalence of NSSI behavior was found in adolescents aged 10-19 years (14.3%), followed by young adults aged 20-29 years (7.0%). The prevalence of NSSI behavior in females was significantly higher than in males (P=16.9 %, χ2=31.322, p<0.000) (P=19.6 %, χ2=11.723, p=0.001) (P=5.9 %, χ2=6.094, p=0.014) ((P=7.7 %, χ2=14.472, p<0.000). The prevalence of NSSI behavior in patients with Personality disorders was significantly higher than in any other diagnostic group (P=46.7%, χ2=195.239, p<0.000). Interpretation: The prevalence of NSSI in patients with mental disorders is high, especially in adolescents. Therefore, it is necessary to inform patients and medical workers how to effectively treat and manage NSSI in order to reduce its occurrence.