Objective: To present an experience report regarding the administration of the neonatal screening referral service in Pará. Based on the implementation of the National Neonatal Screening Program through Ordinance nº 822, of June 6, 2001. Method: This is a descriptive study, with a qualitative approach, of the experience report type, experienced by four nurses who work at the Reference Service in Neonatal Screening at the University of the State of Pará, through systematic, structured or controlled observation. Results: An approach to the work process was carried out based on forwarding through postage to the Research and Diagnostic Support Laboratory responsible for the development of the following steps: 1) sample screening, which is a process of evaluating the quality of the material collected; 2) entering the child's information in the VEGA triage system and 3) processing the biological samples to obtain the results. These procedures are in accordance with the provisions of the Neonatal Screening Technical Manual. Conclusion: In this process, the importance of the multidisciplinary team, especially the nurse, is highlighted in the search for empowerment on the importance of neonatal screening for the early diagnosis of metabolic diseases and the prevention of irreversible sequelae, complications and deaths.

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