Allergic contact dermatitis needs to be considered in patients with eczematous reactions or delayed healing following the use of acrylic-based modern dressings or adhesives. However, identification of the culprit allergen is hampered by poor cooperation from the producers, so adequate labelling of medical devices is an urgent necessity.

No abstract

The term epidermal nevus (EN) is used for mosaic congenital malformations of different components of the skin structures derived from the ectoderm, namely keratinocytic, or non-organoid EN, and sebaceous, follicular or apocrine/eccrine, collectively known as organoid EN. Keratinocytic epidermal nevi (KEN) are characterized clinically by permanent hyperkeratosis in the distribution of Blaschko's lines and histologically by hyperplasia of epidermal keratinocytes. The co-presentation of a KEN with a papular nevus spilus is termed phakomatosis pigmentokeratotica (PPK), in which areas of linear sebaceous nevi (SN) can also sometimes be seen. Mosaic mutations in many genes have been demonstrated in KEN, including KRT1 and KRT10, PIK3CA, FGFR3, AKT1, HRAS, and KRAS. 1 PPK is caused by post-zygotic mutations in HRAS 2 or BRAF 3 in the few cases genotyped thus far. Importantly, some mosaic mutations in KRT1/10 have