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Diagnostic performances of both Zenit RA and HemosIL Acustar were comparable with odds ratios lower limits of CI of 5 for aβ2 GPI IgG for Zenit and Acustar and 6 and 5 for aCl IgG on Zenit and Acustar, respectively. However, even with these new automated systems, titres differed largely between systems, especially for aβ2 GPI IgG.

The use of Zenit G-sight for automated ANA IIF analysis offers opportunities to improve standardization. However, a complementary role of the expert technicians remains, especially for pattern recognition and classification of uncertain/negative samples.

The authors noticed an error in one of our published articles. The terms sensitivity and specificity (but not the numbers) were switched.In the Results section (Analytical performance characteristics of the automated ANA IIF) the following is stated:When the negative/uncertains were categorized as negative, sensitivity stayed high (156/157 = 99%), but specificity decreased towards 52% (n = 69/132)."This should read correctly:When the negative/uncertains were categorized as negative, specificity increased (156/157 = 99%), but sensitivity decreased towards 52% (n = 69/132)."

No abstract