It is concluded that the severity of congenital hypothyroidism, but not the timing of treatment initiation, is an important factor determining long-term cognitive and motor outcome. Clearly, detrimental effects on developmental outcome in patients with congenital hypothyroidism persist over time.

Essentially, findings from the 1992-1993 cohort were similar to those of the 1981-1982 cohort. Apparently, advancing initiation of T(4) supplementation from 28 to 20 d after birth did not result in improved cognitive or motor outcome in CH-T patients.

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Objective The aim of this study was to compare health related quality of life (HRQOL) in infants and children with avoidant restrictive food intake disorder (ARFID) to healthy and chronically ill controls. Method A cross‐sectional study was conducted in children who meet ARFID criteria at our tertiary care pediatric feeding clinic (September 2014 to July 2016). Before consultation, parents of patients ( n = 100) were asked to complete questionnaires to determine HRQOL: the TNO‐AZL Preschool Children Quality of Life (0–5 years), and “Pediatric Quality of Life Inventory” (6–7 and 8–10 years). HRQOL of ARFID patients was compared to both healthy (0–5 years n = 241; 6–7 years n = 61; 8–10 years n = 192) and chronically ill (0–5 years n = 79; 6–7 years n = 11; 8–10 years n = 26) controls. Results The prevalence of ARFID was 64%. HRQOL of ARFID patients aged 0–5 years ( n = 37) was significantly lower on 6/12 scales (appetite, lungs, stomach, motor functioning, positive mood and liveliness) compared to healthy controls ( P < .01), and on 4/12 scales (appetite, stomach, motor functioning, and liveliness) compared to chronically ill controls ( P < .01). The ARFID patients scored significantly better on the problem behavior scale compared to healthy and chronically ill controls ( P < .01). ARFID patients aged 6–7 ( n = 9) had significantly lower scores in 3/6 scales (total score, psychosocial health, and school functioning) ( P < .01), and aged 8–10 ( n = 2) had a significantly lower school functioning scale ( P < .01) compared to healthy controls. Conclusion HRQOL of children with ARFID is decreased on multiple scales. The effect on HRQOL should be incorporated in clinical practice, and clinical studies should add HRQOL as an outcome measure.