The present study was undertaken to determine the main metabolic secretory signals generated by the mitochondrial substrate MeS (methyl succinate) compared with glucose in mouse and rat islets and to understand the differences. Glycolysis and mitochondrial metabolism both have key roles in the stimulation of insulin secretion by glucose. Both fuels elicited comparable oscillatory patterns of Ca 2+ and changes in plasma and mitochondrial membrane potential in rat islet cells and clonal pancreatic β-cells (INS-1). Saturation of the Ca 2+ signal occurred between 5 and 6 mM MeS, while secretion reached its maximum at 15 mM, suggesting operation of a K ATP -channel-independent pathway. Additional responses to MeS and glucose included elevated NAD(P)H autofluorescence in INS-1 cells and islets and increases in assayed NADH and NADPH and the ATP/ADP ratio. Increased NADPH and ATP/ADP ratios occurred more rapidly with MeS, although similar levels were reached after 5 min of exposure to each fuel, whereas NADH increased more with MeS than with glucose. Reversal of MeS-induced cell depolarization by Methylene Blue completely inhibited MeS-stimulated secretion, whereas basal secretion and KCl-induced changes in these parameters were not affected. MeS had no effect on secretion or signals in the mouse islets, in contrast with glucose, possibly due to a lack of malic enzyme. The data are consistent with the common intermediates being pyruvate, cytosolic NADPH or both, and suggest that cytosolic NADPH production could account for the more rapid onset of MeS-induced secretion compared with glucose stimulation.

Last few decades, several economic uncertainty challenges have emerged in the energy market. This study newly contributes to existing research by inspecting the asymmetric effect of economic policy uncertainty and financial development on renewable energy consumption in China. We employ a nonlinear ARDL approach by using a time-series dataset spanning from 1990 to 2019. Our symmetric model shows that economic policy uncertainty matters in the short run, as it increases renewable energy consumption while exhibiting a negative impact on renewable energy in long run in China. Our asymmetric results in the short and long run have deviated from the symmetric results. Our asymmetric results of the short and long run are similar in direction but different in magnitude. The results show that positive change in economic policy uncertainty has increased 3.216% and negative change in economic policy uncertainty has decreased 1.461% in renewable energy consumption in long run in China. Financial development does not matter in renewable energy consumption in China. Based on these outcomes, we can draw some robust economic policies in China as well as for other pollutant economies. Policymakers should be made economic policies more predictable in the modern era.

The oxidation of a simple p-methoxyphenol derivative by HClO induces an intramolecular charge transfer from the end phenyl units to the middle benzoquinone, which leads to colorimetric and fluorescent changes. This detection can be run in aqueous solution with high selectivity over other reactive oxygen species.

In this paper, the design of the optimal decentralized state-feedback controllers is considered for a wireless sensor and actuator network (WSAN) with stochastic network-induced delays and packet losses. In particular, taking advantage of multiple controllers, we model the WSAN as a wireless networked control system (NCS) with decentralized controllers, and then formulate the stochastic optimal state-feedback control problem as a non-cooperative linear quadratic (LQ) game. The optimal control law of each controller is obtained that is a function of the current plant state and all past control signals. The performance of the proposed stochastic optimal control algorithm is investigated using both a genetic control system and a load frequency control (LFC) system in power grid. Index TermsWireless sensor and actuator network (WSAN), networked control system (NCS), decentralized controllers, delays, packet losses, non-cooperative game.

In this study, the design of the optimal decentralised full-state-feedback controllers is derived for wireless networked control systems with network-induced delays. In particular, the authors formulate the optimal decentralised control problem as a non-cooperative linear quadratic game. Then, the optimal control strategy of each controller is obtained that is based on the current plant state and the last control strategies of decentralised controllers. The proposed optimal decentralised controllers reduce to the known controller under certain conditions. Moreover, the authors illustrate the application of the proposed decentralised state feedback control to load frequency control in power grid systems.