In this work, a biomimetic nanozyme catalyst with rapid and efficient self-bacteria-killing and wound-healing performances was synthesized. Through an in situ reduction reaction, a PCN-222 metal organic framework (MOF) was doped with bismuth nanoparticles (Bi NPs) to form Bi-PCN-222, an interfacial Schottky heterojunction biomimetic nanozyme catalyst, which can kill 99.9% of Staphylococcus aureus (S. aureus). The underlying mechanism was that Bi NP doping can endow Bi-PCN-222 MOF with self-driven charge transfer through the Schottky interface and the capability of oxidaselike and peroxidase-like activity, because a large number of free electrons can be captured by surrounding oxygen species to produce radical oxygen species (ROS). Furthermore, once bacteria contact Bi-PCN-222 in a physiological environment, its appropriate redox potential can trigger electron transfer through the electron transport pathway in bacterial membranes and then the interior of the bacteria, which disturbs the bacterial respiration process and subsequent metabolism. Additionally, Bi-PCN-222 can also accelerate tissue regeneration by upregulating fibroblast proliferation and angiogenesis genes (bFGF, VEGF, and HIF-1α), thereby promoting wound healing. This biomimetic enzyme-catalyzed strategy will bring enlightenment to the design of self-bacterial agents for efficient disinfection and tissue reconstruction simultaneously.

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Bismuth metal–organic frameworks (MOFs) as catalysts are scarce. Herein, the first MOF comprising meso‐ tetra(4‐carboxyphenyl) porphine (TCPP) as an organic ligand and Bi ion as a metal node, denoted as Bi‐TCPP, is synthesized by a convenient one‐step hydrothermal method. Compared to other 2D (Cu‐TCPP) or 3D (PCN‐222) MOFs with TCPP as a ligand, Bi‐TCPP has ultrafast singlet oxygen generation ability and a high photothermal conversion efficiency of 49.5% under the irradiation of 660 nm light. This is due to Bi‐TCPP's strong ligand‐to‐metal charge transfer (LMCT) events that form singlet oxygen (1O2). Further, when the electrons and holes above the bandgap relax to the band edge, the excess energy is converted into heat. In vitro and in vivo experiments show excellent antibacterial and repair effects. Hence, the synthesis of Bi‐TCPP provides new ideas for the study of rare bismuth‐based MOFs, and its excellent biocompatibility provides a possibility for further application.